Kluver Memorial Symposium: Biomarkers and Clinical Trials in Neurovascular Disease

Chicago, IL US
September 12, 2018
A number of rare neurovascular pathologies contribute to the burden of stroke and resulting disabilities and death. Dozens of pathologic entities have been studied extensively with genetic contributions and molecular mechanisms well elucidated. Extensive laboratory research has linked these diseases to faithful biomarkers and realistic therapeutic targets. Nevertheless, these advances have remained an “embarrassment of riches” without meaningful clinical applications. Much of the obstacles relate to the paucity of applicable methodologies of clinical and analytic biomarker validations, multisite reproducibility, and realistic clinical trial designs.
This is beginning to change with a number of novel scientific tools and strategies bridging the bedside to the clinic. This workshop brings together scientists and clinicians to explore some of these advances and their application to specific neurovascular diseases.

Learning Objectives and Target Audience

At the conclusion of this activity, the learner will be able to:

  • Describe trial design, including novel Bayesian methods, applicable to Phase I and II trials of rare diseases;
  • State the categories of biomarkers, their analytic and clinical validation, and potential certification;
  • Discuss strategies for deploying biomarkers and novel trial designs in specific neurovascular diseases;
  • Recall newly funded NIND/NIH initiatives in trial readiness and proof of concept trial applied to cavernous angiomas with symptomatic hemorrhage (CASH).
This activity is designed for students, residents, fellows and other trainees at all levels, and clinicians and scientists in neuroscience, biostatistics, computational biology, neurobiology, neurology, neurosurgery, pathology, neuroradiology interested in bench and clinical science related to neurovascular diseases.
Additional information
ABMS Core Competencies: 
Medical Knowledge
For more information, please contact:
CME Coordinator Contact Name: 
Daniel Nava
CME Coordinator Contact Email: 
CME Coordinator Contact Phone: 
Available credit: 
  • 3.25 AMA PRA Category 1 Credit™
  • 3.25 Participation
Event starts: 
09/12/2018 - 4:00pm
Event ends: 
09/12/2018 - 9:00pm
Activity opens: 
Activity expires: 

Agenda subject to change.

Gleacher Center
9450 Cityfront Plaza Dr
Chicago, IL 60611
United States
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ACCESSIBILITY The University of Chicago is committed to providing equal access appropriate to need and circumstances and complies fully with legal requirements of the Americans with Disabilities Act. If you are in need of special accommodation, please contact our office at 773-702-5595 or via email at dnava@surgery.bsd.uchicago.edu.

 The University of Chicago reserves the right to cancel or postpone this conference due to unforeseen circumstances. In the unlikely event this activity must be cancelled or postponed, the registration fee will be refunded; however, The University of Chicago is not responsible for any related costs, charges, or expenses to participants, including fees assessed by airline/travel/lodging agencies.

  David Frim, MD, PhD
  Section Chief of Neurosurgery
  The University of Chicago

  Issam Awad, MD
  John Harper Seeley Professor of Surgery
  Director, Neurovascular Surgery
  Director, Safadi Program of Excellence in Clinical and Translational Neuroscience

Disclosure Declarations
As a provider accredited by the ACCME, The University of Chicago Pritzker School of Medicine asks everyone who is in a position to control the content of an education activity to disclose all relevant financial relationships with any commercial interest. This includes any entity producing, marketing, re-selling, or distributing health care goods or services consumed by or used on patients. The ACCME defines “relevant financial relationships” as financial relationships in any amount occurring within the past 12 months, including financial relationships of a spouse or life partner that could create a conflict of interest. Mechanisms are in place to identify and resolve any potential conflict of interest prior to the start of the activity.

Additionally, The University of Chicago Pritzker School of Medicine requires authors to identify investigational products or off-label uses of products regulated by the US Food and Drug Administration, at first mention and where appropriate in the content.

Physician Credit
The University of Chicago Pritzker School of Medicine is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.

The University of Chicago Pritzker School of Medicine designates this live activity for a maximum of 3.25 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
Other Health Professions Credit
Nurses and other healthcare professionals will receive a Certificate of Participation. For information on the applicability and acceptance of Certificates of Participation for educational activities certified for AMA PRA Category 1 Credit™ from organizations accredited by the ACCME, please consult your professional licensing board.
Please Note: The credit claiming process will close three months after the conference end date. Requests to claim credit after three months will be subject to additional fees.

Accreditation Period

Activity opens: 
Activity expires: 
Registration:  To RSVP, please e-mail us by clicking the button below.

Claiming Credit: Enter the access code to unlock the credit claiming process.
Please Note: The credit claiming process will close three months after the conference end date. Requests to claim credit after three months will be subject to additional fees.
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