UChicago Medicine Primary Care e-Journal Club: Effect of Colonoscopy Screening on Risks of Colorectal Cancer and Related Death

December 1, 2022 to December 31, 2022
This activity will use an asynchronous e-learning model to engage with high-impact updates in primary care literature that will improve patient care.
This paper reports the results of NordICC, a pragmatic trial randomizing 84,585 healthy 55- to 64-year-old men and women from Poland, Norway, Sweden, and the Netherlands in a 1:2 fashion to receive an invitation to have a screening colonoscopy or receive their usual care. The study enrolled patients from 2009 to 2014 and continued to follow patients for a median of 10 years.
Data supporting colonoscopy have relied on cohort studies. Previous estimates from these studies have estimated that colonoscopy screening is associated with a 40 to 69% decrease in colon cancer incidence and a 29 to 88% decrease in colon cancer death. Cohort studies can overestimate the actual benefit of screening because they may not be able to control for factors that can probably lead cohort studies to overestimate the real-world effectiveness of colonoscopy because of the inability to adjust incomplete adherence to screening recommendations. Other colon cancer screening modalities (FOBT, Sigmoidoscopy) have had RCT-level data.

Target Audience

This activity is designed for physicians and other healthcare professionals providing primary care to patients at UChicago Medicine.

Learning Objectives

After this activity, participants will be able to:

  • Compare intention to treat to per-protocol analysis methods for screening tests;
  • Discuss the impact of adherence to real-world screening recommendations;
  • Identify the risks and benefits of colonoscopy.
Additional information
ACGME/ABMS Core Competencies: 
Patient Care and Procedural Skills
Medical Knowledge
For more information, please contact:
CME Coordinator Contact Name: 
Katherine Sullivan
CME Coordinator Contact Email: 
CME Coordinator Contact Phone: 
Available credit: 
  • 1.00 AMA PRA Category 1 Credit™
  • 1.00 Participation
Event starts: 
12/01/2022 - 12:00am
Event ends: 
12/31/2022 - 11:59pm
Activity opens: 
Activity expires: 
  George Weyer, MD
  Assistant Professor of Medicine



Disclosure Declarations
As a provider accredited by the ACCME, The University of Chicago Pritzker School of Medicine asks everyone in a position to control the content of an education activity to disclose all financial relationships with any ineligible companies. This includes any entity whose primary business is producing, marketing, selling, re-selling, or distributing healthcare products used by or on patients. Financial relationships are relevant if a financial relationship, in any amount, exists between the person in control of content and an ineligible company during the past 24 months, and the content of the education is related to the products of an ineligible company with whom the person has a financial relationship. Mechanisms are in place to identify and mitigate any relevant financial relationships prior to the start of the activity.

Additionally, The University of Chicago Pritzker School of Medicine requires Authors to identify investigational products or off-label uses of products regulated by the US Food and Drug Administration at first mention and where appropriate in the content.
Physician Credit
The University of Chicago Pritzker School of Medicine is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.
The University of Chicago Pritzker School of Medicine designates this enduring material for a maximum of 1 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
Other Healthcare Professional Credit
Other healthcare professionals will receive a Certificate of Participation. For information on the applicability and acceptance of Certificates of Participation for educational activities certified for AMA PRA Category 1 Credit™ from organizations accredited by the ACCME, please consult your professional licensing board.
Please Note: The credit claiming process will close three months after the conference end date. Requests to claim credit after three months will be subject to additional fees.
Registration: This course is only open to University of Chicago affiliates.
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