Monogenic Diabetes in Pregnancy

An On-Demand Webinar
 
In this activity, we'll dive into managing some of the most prevalent forms of monogenic diabetes in pregnancy. From GCK-MODY to HNF1A- and HNF4A-MODY, HNF1B-MODY, and ABCC8 and KCNJ11-related diabetes, we'll cover it all. By the end of this session, you'll better understand how precision medicine plays a crucial role in managing monogenic diabetes during pregnancy. We'll also review potential adverse outcomes and explore the use of cell-free DNA in prenatal diagnosis testing. Join us to enhance your knowledge and improve patient care!
 
Medium: Video with PPT, eLearning
Activity Length: 30 minutes
Test Time: 6 minutes
 
This presentation was originally recorded at Celebrating Miracles and Milestones 2022: Monogenic Diabetes Professional Education on July 22, 2022.

Target Audience

This activity is designed for adult and pediatric endocrinologists, family practice and internal medicine physicians, pediatricians, adult and pediatric nurse practitioners, certified diabetes care and education specialists, pediatric nurses, and other healthcare professionals dedicated to providing high-quality care to patients with MDM.

Learning Objectives

After this activity, participants will be able to:

  • Summarize the general considerations and implications of diabetes in pregnancy, including maternal and fetal risks, optimal glucose control, monitoring techniques, and potential complications;
  • Describe the most common forms of monogenic diabetes during pregnancy by outlining appropriate medical interventions, personalized treatment plans, and multidisciplinary care approaches that encompass genetic counseling, nutritional management, medication adjustments, and monitoring strategies.

Commercial Support: This CME-certified activity has not requested or received any support or funding from commercial interests. This includes but is not limited to, pharmaceutical companies and medical device manufacturers.

Additional information
ACGME/ABMS Core Competencies: 
Patient Care and Procedural Skills
Medical Knowledge
For more information, please contact:
CME Coordinator Contact Name: 
Lisa Letourneau-Freiberg
CME Coordinator Contact Email: 
monogenicdiabetes@uchicago.edu
Summary
Available credit: 
  • 0.50 AMA PRA Category 1 Credit™
  • 0.50 Nursing Contact Hours
  • 0.50 Participation
Activity opens: 
06/21/2023
Activity expires: 
06/21/2025
Part of: 
Identifying and Managing Patients with Monogenic Diabetes
UNIVERSITY OF CHICAGO FACULTY
  Laura Dickens, MD
  Assistant Professor of Medicine
  Co-Director, Diabetes in Pregnancy Program

 



PUBLICATIONS
View a partial list of Dr. Dicken's publications through the National Library of Medicine's PubMed online database.
ADDITIONAL RESOURCES
Pregnancy outcome in patients with raised blood glucose due to a heterozygous glucokinase gene mutation https://pubmed.ncbi.nlm.nih.gov/19125755/
 
Recognition and Management of Individuals With Hyperglycemia Because of a Heterozygous Glucokinase Mutation https://pubmed.ncbi.nlm.nih.gov/26106223/
 
Evaluation of pregnancy outcomes in women with GCK-MODY https://pubmed.ncbi.nlm.nih.gov/33277730/
 
Management and pregnancy outcomes of women with GCK-MODY enrolled in the US Monogenic Diabetes Registry https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6468988/
 
Noninvasive Fetal Genotyping by Droplet Digital PCR to Identify Maternally Inherited Monogenic Diabetes Variants https://pubmed.ncbi.nlm.nih.gov/32533152/
 
Macrosomia and hyperinsulinaemic hypoglycaemia in patients with heterozygous mutations in the HNF4A gene https://pubmed.ncbi.nlm.nih.gov/17407387/
 
Management of sulfonylurea-treated monogenic diabetes in pregnancy: implications of placental glibenclamide transfer https://pubmed.ncbi.nlm.nih.gov/28556992/
 
Hepatocyte nuclear factor-1 beta mutations cause neonatal diabetes and intrauterine growth retardation: support for a critical role of HNF-1beta in human pancreatic development https://pubmed.ncbi.nlm.nih.gov/17116179/
 
Precision Medicine: Long-Term Treatment with Sulfonylureas in Patients with Neonatal Diabetes Due to KCNJ11 Mutations https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6894166/
 
Analysis of cell-free fetal DNA for non-invasive prenatal diagnosis in a family with neonatal diabetes https://pubmed.ncbi.nlm.nih.gov/27477181/


Disclosure Declarations
As a provider accredited by the ACCME, The University of Chicago Pritzker School of Medicine asks everyone in a position to control the content of an education activity to disclose all financial relationships with any ineligible companies. This includes any entity whose primary business is producing, marketing, selling, re-selling, or distributing healthcare products used by or on patients. Financial relationships are relevant if a financial relationship, in any amount, exists between the person in control of content and an ineligible company during the past 24 months, and the content of the education is related to the products of an ineligible company with whom the person has a financial relationship. Mechanisms are in place to identify and mitigate any relevant financial relationships prior to the start of the activity.

Additionally, The University of Chicago Pritzker School of Medicine requires Authors to identify investigational products or off-label uses of products regulated by the US Food and Drug Administration at first mention and where appropriate in the content.
 
The following individuals have no relevant financial relationships with ineligible companies to disclose:
Siri Atma Greeley, MD, PhD
Peggy Hasenauer, MS, RN
Lisa Letourneau-Freiberg, MPH, RD, LDN
Rochelle Naylor, MD
 
Laura Dickens, MD has no relevant relationships with ineligible companies to disclosure. Dr. Dickens will discuss FDA off-label use of sulfonylureas for monogenic diabetes.

Louis Philipson, MD, PhD has received research funding from Novo Nordisk, Dompe, and Protect Bio and has served on the advisory board of Nevro.

The Center for Continuing Medical Education staff have no relevant financial relationships with ineligible companies to disclose.

All of the relevant financial relationships listed for these individuals have been mitigated.
Physician Credit
The University of Chicago Pritzker School of Medicine is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.
 
The University of Chicago Pritzker School of Medicine designates this enduring material for a maximum of 0.50 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
 
Nursing Credit
University of Chicago Medicine is accredited as a provider of nursing continuing professional development by the American Nurses Credentialing Center's Commission on Accreditation.

Participants who successfully complete the entire activity and complete an evaluation form will earn 0.50 contact hours.

Other Healthcare Professional Credit
Other healthcare professionals will receive a Certificate of Participation. For information on the applicability and acceptance of certificates of participation for educational activities certified for AMA PRA Category 1 Credit™ from organizations accredited by the ACCME, please consult your professional licensing board.
Instructions for Participation and Claiming Credit
 
This online educational activity (enduring material) is designed to be completed within the time designated. To successfully earn credit, participants must complete the activity online during the valid credit period. To receive a certificate, the participant must watch the complete video presentation and correctly answer all questions (100% pass rate) on the post-test. The activity can be accessed by simply clicking "Complete Activity" and watching the video presentation. Once finished, you will be able to proceed to the post-test. Upon successful completion, the participant may claim credit and save or print their certificate.
 
Physicians and nurses are eligible to receive continuing education credit applicable to their profession. All other participants will receive a certificate indicating participation in this AMA PRA Category 1 Credit™-approved activity. For information on the applicability and acceptance of certificates of participation for educational activities certified for AMA PRA Category 1 Credit™ from organizations accredited by the ACCME, please consult your professional licensing board.
 
For questions about CME credit or technical issues, please contact the Center for CME at the University of Chicago at cme@bsd.uchicago.edu.
 
DISCLAIMER  The information presented in this activity is for continuing medical education purposes only. The opinions expressed in this educational activity are those of the faculty and do not necessarily represent the views of the University of Chicago Pritzker School of Medicine, the University of Chicago Medicine, or the Department/Section.
 
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