Establishing Frameworks for Precision Medicine in NTRK Fusion-Positive Advanced Solid Tumors

Despite significant advancements over the past decade, significant unmet needs persist for patients with NTRK-positive locally advanced or metastatic solid tumors. In addition, there is ongoing debate about the importance of testing for genomic alterations in rare cancers, or those that rarely occur in common cancers. However, evolving molecular testing procedures and emerging therapeutic options targeting NTRK fusions offer new pathways for the detection and treatment of these cancers. To help clinicians enhance their diagnostic-therapeutic paradigms for rare genomic alterations, this interactive practice guide interweaves education and practical guidance for easy integration of the latest testing and treatment strategies within daily clinical processes and workflows.
 
Educational Partner: Academy for Continued Healthcare Learning (ACHL)

Medium: Interactive Practice Guide

Commercial Support: Supported by an educational grant from Bristol Myers Squibb.

Target Audience

This activity is created for medical oncologists, pathologists, nurse practitioners, physician assistants and APNs who care for patients with NTRK fusion-positive cancers.

Learning Objectives

Upon completion of this activity, participants will be able to:

  • Review optimal testing strategies to detect NTRK fusions in patients with cancer
  • Assess efficacy and safety data of current and emerging TRK inhibitors for patients with NTRK fusion-positive advanced solid tumors
  • Establish operational frameworks to improve precision medicine practices in patients with NTRK fusion-positive cancers
Additional information
ACGME/ABMS Core Competencies: 
Patient Care and Procedural Skills
Medical Knowledge
Practice-based Learning and Improvement
Interpersonal and Communication Skills
For more information, please contact:
CME Coordinator Contact Name: 
McKenna Reinhard
CME Coordinator Contact Email: 
mreinhard@achlcme.org
CME Coordinator Contact Phone: 
(773) 714-0705 ext. 121

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Disclosure Declarations
As a provider accredited by the ACCME, The University of Chicago Pritzker School of Medicine asks everyone in a position to control the content of an education activity to disclose all financial relationships with any ineligible companies. This includes any entity whose primary business is producing, marketing, selling, re-selling, or distributing healthcare products used by or on patients. Financial relationships are relevant if a financial relationship, in any amount, exists between the person in control of content and an ineligible company during the past 24 months, and the content of the education is related to the products of an ineligible company with whom the person has a financial relationship. Mechanisms are in place to identify and mitigate any relevant financial relationships prior to the start of the activity.

Additionally, The University of Chicago Pritzker School of Medicine requires Authors to identify investigational products or off-label uses of products regulated by the US Food and Drug Administration at first mention and where appropriate in the content.
Physician Credit
The University of Chicago Pritzker School of Medicine is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

The University of Chicago Pritzker School Of Medicine designates this enduring material for a maximum of 1 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
 
Physician assistants, nurse practitioners, and nurses may participate in this educational activity and earn a certificate of completion as AAPA, AANP, and ANCC accept AMA PRA Category 1 Credits™ through their reciprocity agreements.
 
Completion of this activity, including the pretest, posttest, and follow-up assessments, qualifies as a medium weight MIPS improvement activity under MACRA and can be claimed as completion of IA_PSPA 28 of an Accredited Safety or Quality Improvement Program in the Quality Payment Program. Clinicians should submit their improvement activities by attestation via the CMS Quality Payment Program website. You will receive additional information after completing the activity and receiving your certificate via email.
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