Groups at increased risk of colon cancer include patients with familial cancer syndromes and inflammatory bowel disease. Identification of risk factors in these patients and implementation of increased surveillance with enhanced imaging during colonoscopy can lead to earlier detection of neoplastic lesions in the colon. Chromoendoscopy is a type of “image-enhanced endoscopy” that uses dye spray or advanced optical technology. Recent studies have shown “chromeoendoscopy with targeted biopsies was less costly and more effective than white-light colonoscopy with random biopsies.” Although it can be a highly valuable procedure, experts in the field agree it is greatly underutilized. This activity will bridge that practice gap by helping gastroenterologists understand the indications for increasing surveillance in high risk populations and applications of chromoendoscopy in clinical practice.