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Maturity-Onset Diabetes of the Young Due to HNF1B Mutations
An On-Demand Webinar
Join us for an insightful review of the crucial role hepatocyte nuclear factor 1β plays in the body and its impact on MODY. Our session will delve into the clinical presentation of HNF1B variants, highlighting the significance of accurate diagnosis and effective management. We will also explore 17q12 Recurrent Deletion Syndrome and its associated features. Don't miss out on this informative discussion!
Medium: Video with PPT, eLearning
Activity Length: 16 minutes
Test Time: 4 minutes
Activity Length: 16 minutes
Test Time: 4 minutes
This presentation was originally recorded at Celebrating Miracles and Milestones 2022: Monogenic Diabetes Professional Education on July 22, 2022.
Target Audience
This activity is designed for adult and pediatric endocrinologists, family practice and internal medicine physicians, pediatricians, adult and pediatric nurse practitioners, certified diabetes care and education specialists, pediatric nurses, and other healthcare professionals dedicated to providing high-quality care to patients with MDM.
Learning Objectives
After this activity, participants will be able to:
- Recall the pivotal role of hepatocyte nuclear factor 1β (HNF1B) in the pathogenesis of MODY, encompassing its impact on beta-cell function, glucose metabolism, and overall regulation of diabetes;
- Characterize the specific clinical presentation and features associated with MODY caused by HNF1B genetic variants, including both typical and atypical manifestations, such as renal abnormalities and extra-pancreatic involvement;
- Discuss the optimal management strategies, including lifestyle interventions, pharmacotherapy options, and the role of genetic counseling, for individuals with MODY due to HNF1B variants;
- Evaluate the long-term prognosis, potential complications, and appropriate monitoring considerations specific to this particular subtype of MODY.
Commercial Support: This CME-certified activity has not requested or received any support or funding from commercial interests. This includes but is not limited to, pharmaceutical companies and medical device manufacturers.
FACULTY
PUBLICATIONS
View a partial list of Dr. Bermonth's publications through the National Library of Medicine's PubMed online database.
ADDITIONAL RESOURCES
17q12 Recurrent Deletion Syndrome https://www.ncbi.nlm.nih.gov/books/NBK401562/
HNF1B-associated renal and extra-renal disease-an expanding clinical spectrum https://pubmed.ncbi.nlm.nih.gov/25536396/
Expanded Clinical Spectrum in Hepatocyte Nuclear Factor 1B-Maturity-Onset Diabetes of the Young https://academic.oup.com/jcem/article/94/7/2658/2597537
HNF1B-associated renal and extra-renal disease-an expanding clinical spectrum https://pubmed.ncbi.nlm.nih.gov/25536396/
Expanded Clinical Spectrum in Hepatocyte Nuclear Factor 1B-Maturity-Onset Diabetes of the Young https://academic.oup.com/jcem/article/94/7/2658/2597537
Disclosure Declarations
As a provider accredited by the ACCME, The University of Chicago Pritzker School of Medicine asks everyone in a position to control the content of an education activity to disclose all financial relationships with any ineligible companies. This includes any entity whose primary business is producing, marketing, selling, re-selling, or distributing healthcare products used by or on patients. Financial relationships are relevant if a financial relationship, in any amount, exists between the person in control of content and an ineligible company during the past 24 months, and the content of the education is related to the products of an ineligible company with whom the person has a financial relationship. Mechanisms are in place to identify and mitigate any relevant financial relationships prior to the start of the activity.
Additionally, The University of Chicago Pritzker School of Medicine requires Authors to identify investigational products or off-label uses of products regulated by the US Food and Drug Administration at first mention and where appropriate in the content.
The following individuals have no relevant financial relationships with ineligible companies to disclose:
Siri Atma Greeley, MD, PhD
Peggy Hasenauer, MS, RN
Lisa Letourneau-Freiberg, MPH, RD, LDN
Rochelle Naylor, MD
Maria Salguero Bermonth, MD, MSc
Louis Philipson, MD, PhD has received research funding from Novo Nordisk, Dompe, and Protect Bio and has served on the advisory board of Nevro.
The Center for Continuing Medical Education staff have no relevant financial relationships with ineligible companies to disclose.
All of the relevant financial relationships listed for these individuals have been mitigated.
Siri Atma Greeley, MD, PhD
Peggy Hasenauer, MS, RN
Lisa Letourneau-Freiberg, MPH, RD, LDN
Rochelle Naylor, MD
Maria Salguero Bermonth, MD, MSc
Louis Philipson, MD, PhD has received research funding from Novo Nordisk, Dompe, and Protect Bio and has served on the advisory board of Nevro.
The Center for Continuing Medical Education staff have no relevant financial relationships with ineligible companies to disclose.
All of the relevant financial relationships listed for these individuals have been mitigated.
Physician Credit
The University of Chicago Pritzker School of Medicine is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.
The University of Chicago Pritzker School of Medicine is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.
The University of Chicago Pritzker School of Medicine designates this enduring material for a maximum of 0.25 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
Nursing Credit
University of Chicago Medicine is accredited as a provider of nursing continuing professional development by the American Nurses Credentialing Center's Commission on Accreditation.
Participants who successfully complete the entire activity and complete an evaluation form will earn 0.25 contact hours.
University of Chicago Medicine is accredited as a provider of nursing continuing professional development by the American Nurses Credentialing Center's Commission on Accreditation.
Participants who successfully complete the entire activity and complete an evaluation form will earn 0.25 contact hours.
Other Healthcare Professional Credit
Other healthcare professionals will receive a Certificate of Participation. For information on the applicability and acceptance of certificates of participation for educational activities certified for AMA PRA Category 1 Credit™ from organizations accredited by the ACCME, please consult your professional licensing board.
Instructions for Participation and Claiming Credit
This online educational activity (enduring material) is designed to be completed within the time designated. To successfully earn credit, participants must complete the activity online during the valid credit period. To receive a certificate, the participant must watch the complete video presentation and correctly answer all questions (100% pass rate) on the post-test. The activity can be accessed by simply clicking "Complete Activity" and watching the video presentation. Once finished, you will be able to proceed to the post-test. Upon successful completion, the participant may claim credit and save or print their certificate.
Physicians and nurses are eligible to receive continuing education credit applicable to their profession. All other participants will receive a certificate indicating participation in this AMA PRA Category 1 Credit™-approved activity. For information on the applicability and acceptance of certificates of participation for educational activities certified for AMA PRA Category 1 Credit™ from organizations accredited by the ACCME, please consult your professional licensing board.
For questions about CME credit or technical issues, please contact the Center for CME at the University of Chicago at cme@bsd.uchicago.edu.
DISCLAIMER The information presented in this activity is for continuing medical education purposes only. The opinions expressed in this educational activity are those of the faculty and do not necessarily represent the views of the University of Chicago Pritzker School of Medicine, the University of Chicago Medicine, or the Department/Section.
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