- Dapagliflozin reduces the risk of kidney failure in patients with CKD but can result in a reversible acute reduction in eGFR on initiation of treatment
- DAPA-CKD trial found that patients who experienced an acute reduction in eGFR>10% after 2 weeks of treatment with dapagliflozin had slower rates of long-term eGFR decline compared with patients who experienced a less pronounced decline or increase in eGFR.
- A modest acute reduction in eGFR on dapagliflozin initiation is not associated with higher rates of CKD progression and should not be a reason to discontinue this therapy in the majority of patients.
09/23/2022 - 12:00pm to 1:00pm CDT
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- 1.00 AMA PRA Category 1 Credit™
- 1.00 Participation
Tushar Bajaj, MD