Learning Objectives:

1. To understand the pathophysiology of Autosomal Dominant Polycystic Kidney Disease.
2. To define underlying mechanisms of Cyst formation.
3. Demonstrate the CFTR modulators reduce the factors that fuel cyst growth thereby reducing and /or preventing cyst growth.
4. Provide a new strategy for reducing cyst growth by reversing the phenotype of cysts from secretory to absorptive.