Michael Macklin, MD, PharmD

Assistant Professor of Medicine

Section of Rheumatology

 “Genetic mutations in multisystem autoimmune disease: A case of SLE, atypical HUS overlap, an under recognized entity?”

Learning objectives: Discuss a clinical case of lupus nephritis/atypical HUS overlap.

Discuss genetic mutations in atypical HUS.

Lin Shen, MD, PhD

Assistant Professor of Medicine

Section of Rheumatology

 “Studying Monogenic Immune Disorders to Elucidate the Mechanisms of Autoimmune Diseases”

Learning objectives: Discuss recent progress on our understanding of immune tolerance mechanisms by studying genetic variants associated with immune dysregulatory disorders.

Review normal T cell antigen receptor (TCR) signaling, and discuss the impact of abnormal TCR signaling on immune tolerance.