Learning Objectives:

  1. Review definition, prevalence and clinical significance of Clonal Hematopoiesis of Indeterminate Significance (CHIP)
  2. Discuss the link between TET2 mutated CHIP and bacterial driven systemic inflammation in mice
  3. Explore the mechanisms underlying the pro-inflammatory dysregulation in TET2 deficient macrophages
  4. Discuss our endeavor to delineate the role of bacterial driven inflammation in progression from CHIP to hematologic malignancies in humans


  1. To describe current methods non-invasive monitoring for immunotherapy response
  2. To describe novel, predictive, peripheral biomarkers of immunotherapy response
  3. To present phase 1 trials testing novel strategies to overcome specific mechanisms of immunotherapy resistance
Session date: 
10/22/2018 - 12:00pm to 1:00pm CDT
5841 South Maryland Avenue
MC2115 HemOnc Conference Room E215
Chicago, IL 60637
United States
  • 1.00 AMA PRA Category 1 Credit™
  • 1.00 Participation

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Speaker Name: 
Dr. Afaf Osman and Dr. Daniel Olson