Objectives:

1. Review the evidence supporting the link between the gut microbiota and its effect on anti-cancer treatment
2. Discuss strategies to modulate the gut microbiome to optimize efficacy of immunotherapy
3. Consider potential mechanism by which the gut microbiome regulates immune response

and

1. Provide an overview of pH-negative MPNS in accelerated phase and blast phase
2. Discuss molecular mechanisms behind the development of blast phase
3. Discuss treatment options and assessment of response to treatment