Learning Objectives:

1.  Metabolic rewiring is central to the ability of fibroblasts to synthesize extracellular matrix in wound repair, fibrotic disease and cancer

2.  Increased uptake and oxidation of glucose and glutamine support the bioenergetic and biosynthetic demands of increased ECM synthesis upon profibrotic stimuli

3.  Fibroblasts are metabolically flexible, allowing them to produce ECM even if their canonical nutrient sources are limiting