Learning Objectives:  Chablani

1. Review current first-line treatment options for metastatic urothelial cancer

2. Provide an overview of how antibody drug conjugates work and benefits/shortcomings

3.  Discuss the phase II study that led to the FDA approval of Enfortumab Vedotin in Dec 2019 for metastatic urothelial cancer

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Learning Objectives:  Hawking 

1.  To learn about the history of the medical futility debate.

2.  To develop a framework for thinking through futile cases and approaching families

3.