Learning Objectives:

1.  Identify reasons for the failure of GLP-1 analogues in obesity management, focusing on adherence, pharmacological resistance, and individual metabolic differences.

2.  Compare alternative pharmacological and non-pharmacological strategies for patients who do not respond to GLP-1 analogues.

3.  Create holistic management plans that combine behavioral, dietary, exercise, and psychological interventions with other treatments for complex obesity cases.