Main Content / Key Points
o Section 1: Claudins are important tight junction proteins, some of which form ion channels in the paracellular space that are ion selective and can
pass water.
o Section 2: Claudin-2 is upregulated in some types of colitis and contribute to increased water flux and diarrhea.
o Section 3: Claudin-2 plays an important role in limiting pancreatitis development