At the conclusion of this activity, participants will be able to:

1. Identify key biological hallmarks of aging present in older bladders and in bladders with lower urinary tract symptoms and explain why these findings support the bladder as a target for gerotherapeutic interventions.
2. Explain how chronological aging and accelerated biological aging associated with metabolic syndrome increase the risk of lower urinary tract symptoms.
3. Summarize the rationale and design of a pilot feasibility study evaluating mitochondrial-targeted therapy (MitoQ) for urinary urgency in older women.
4. To understand the association between major depression and biological aging
5. To understand the impact of biological aging on health outcomes in major depression