Learning Objectives:

1. Identify most common mutations associated with GIST
2. Discuss the literature regarding prognosis and management of associated mutations in KIT and PDGFR
3. Identify genes associated with “wild-type” GIST and, in particular, review SDH-associated syndromes

and

Learning Objectives:

1. Describe the differences in the diagnostic criteria of monoclonal gammopathy of undetermined significance, smoldering multiple myeloma (SMM), and multiple myeloma.
2. Detail the prognostic variables that increase the risk of progression of SMM to multiple myeloma.
3. Review the evidence for early intervention in SMM.