Learning Objectives:

1 The quiescent status of hematopoietic stem cells (HSCs), long considered to be strictly protective, has a dark side as it forces HSCs to use error prone DNA repair mechanisms and accumulate mutations.

2 Loss of Sirtuin 7 in aged HSCs leads to protein folding stress in the mitochondria; restoring youthful levels of Sirtuin 7 can rejuvenate aged HSCs.

3 Mesenchymal stromal cells in the HSC bone marrow niche regulate local IGF-1 signaling; the reduction of which reduces fibrosis and myelopoiesis and may increase lifespan.

Session date: 
Monday, December 16, 2019 - 12:00pm to 1:00pm
Speaker Name: 
Mary Mohrin, PhD
Location: 
UCMC
900 East 57th Street
KCBD Auditorium 1103
Chicago, IL 60637
United States
  • 1.00 AMA PRA Category 1 Credit™
  • 1.00 Participation

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