Learning Objectives:

1.    Describe the cellular mechanisms underlying the stimulus-secretion coupling in pancreatic beta cells.

2.   Gain an in-depth understanding of how cytosolic Ca2+ events are mediated by intracellular receptors in pancreatic beta cells, and how this contributes to insulin secretion.

3.   Learn about the importance of studying beta cells not just in isolation, but as part of cell collective in an islet.