Objectives:

  1. Describe the use of PD-L1 gene alterations as a surrogate genetic biomarker for an immune inflamed environment in DLBCL and in predicting response to PD-1 blockade therapy in relapsed/refractory DLBCL patients.
  2. Describe how recently-acquired large genomic datasets will be interrogated to identify DLBCL clusters associated with unique immune signatures.
  3. Describe the use of a genome-wide CRISPR/Cas9 screen to identify lymphoma-intrinsic molecules that regulate phagocytosis by macrophages in the context of CD47-SIRP-alpha axis blockade.
Session date: 
Monday, April 1, 2019 - 12:00pm to 1:00pm
Speaker Name: 
Justin W. Kline, MD; James Godfrey, MD; Michael J. Leukam, MD, MS
Location: 
UCMC
5841 South Maryland Avenue
MC2115 HemOnc Conference Room E215
Chicago, IL 60637
United States
  • 1.00 AMA PRA Category 1 Credit™
  • 1.00 Participation

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