Objectives:

1. Review the role of CYP2D6 in opioid metabolism
2. Review evidence supporting the use of phamacogenomic markers which may predict efficacy, cumulative dosage, and risk of toxicity of codeine, tramadol, oxycodone, hydrocodone, and fentanyl

and

1. Discuss the evidence for definitive local treatment of oligometastatic disease  
2. Discuss the evidence for control of intra-cranial disease with immunotherapy or systemic therapy